6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide

Base Information

Chemical Name:6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide
CAS No.:1446791-07-6
Molecular Formula:C₁₉H₂₇N₇O₂
Molecular Weight:385.469
Hs Code.:

Synonyms:6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide

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Chemical Property of 6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide

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Technology Process of 6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide

There total 6 articles about 6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.3%

: 1446793-34-5
tert-butyl (1S,2R)-2-(6-carbamoyl-5-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate

: 1446791-07-6
6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 1446791-07-6
6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium / tetrahydrofuran; hexane / 1.25 h / -76 - 20 °C / Cooling with ice

2: copper(I) oxide; potassium carbonate; N,N-dimethylethylenediamine; ammonium hydroxide / ethylene glycol / 6 h / 60 °C / Sealed tube; Inert atmosphere

3: acetonitrile / 18 h / 130 °C

4: ammonia / methanol / 5 h / 20 °C / Sealed tube

5: 1-methyl-pyrrolidin-2-one / 43 h / 120 °C

6: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With copper(I) oxide; ammonium hydroxide; n-butyllithium; ammonia; potassium carbonate; N,N-dimethylethylenediamine; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; hexane; dichloromethane; ethylene glycol; acetonitrile;

Reference yield:

: 1446793-28-7
2-(6-aminopyridin-2-yl)propan-2-ol

: 1446791-07-6
6-((1R,2S)-2-aminocyclohexylamino)-4-(6-(2-hydroxypropan-2-yl)pyridin-2-ylamino)pyridazine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 18 h / 130 °C

2: ammonia / methanol / 5 h / 20 °C / Sealed tube

3: 1-methyl-pyrrolidin-2-one / 43 h / 120 °C

4: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With ammonia; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; acetonitrile;