1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

Base Information

• Chemical Name: 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole
• CAS No.: 316364-80-4
• Molecular Formula: C₂₆H₂₄N₄O₃S
• Molecular Weight: 472.568
• Mol file: 316364-80-4.mol

Synonyms:1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

Chemical Property of 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

There total 3 articles about 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(tert-butylamino)sulfonylphenylboronic acid (150691-04-6) + 1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-6-carbonitrile (202124-50-3) → 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole (316364-80-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; for 16h; Heating;

DOI:10.1021/jm000113t

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) → 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole (316364-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: tetrahydrofuran / 2 h / Heating

2.1: 97 percent / aq. Na₂CO₃; Pd(PPh₃)4 / tetrahydrofuran / 16 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In tetrahydrofuran; 2.1: Suzuki coupling;

DOI:10.1021/jm000113t

Reference yield:

1H-benzo[d]imidazole-6-carbonitrile (6287-83-8) → 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole (316364-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: tetrahydrofuran / 2 h / Heating

2.1: 97 percent / aq. Na₂CO₃; Pd(PPh₃)4 / tetrahydrofuran / 16 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In tetrahydrofuran; 2.1: Suzuki coupling;

DOI:10.1021/jm000113t

upstream raw materials:

2-(tert-butylamino)sulfonylphenylboronic acid

1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-6-carbonitrile

para-bromophenacyl bromide

1H-benzo[d]imidazole-6-carbonitrile