1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

Base Information

Chemical Name:1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole
CAS No.:316364-80-4
Molecular Formula:C₂₆H₂₄N₄O₃S
Molecular Weight:472.568
Hs Code.:

Synonyms:1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

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Chemical Property of 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

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Technology Process of 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

There total 3 articles about 1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 150691-04-6
2-(tert-butylamino)sulfonylphenylboronic acid

: 202124-50-3
1-[2-(4-bromophenyl)-2-oxoethyl]-1H-benzimidazole-6-carbonitrile

: 316364-80-4
1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; for 16h; Heating;
DOI:10.1021/jm000113t

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 316364-80-4
1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: tetrahydrofuran / 2 h / Heating

2.1: 97 percent / aq. Na₂CO₃; Pd(PPh₃)4 / tetrahydrofuran / 16 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In tetrahydrofuran; 2.1: Suzuki coupling;
DOI:10.1021/jm000113t

Reference yield:

: 6287-83-8
1H-benzo[d]imidazole-6-carbonitrile

: 316364-80-4
1N-(4'-(o-tert-butylaminosulfonylphenyl)phenylcarbonyl)methyl-6-cyanobenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 20 °C

1.2: tetrahydrofuran / 2 h / Heating

2.1: 97 percent / aq. Na₂CO₃; Pd(PPh₃)4 / tetrahydrofuran / 16 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In tetrahydrofuran; 2.1: Suzuki coupling;
DOI:10.1021/jm000113t