(+/-)-4-tert-butyl-3-cyano-1-(4-trimethylsilaethynylphenyl)-2,6,7-trioxabicyclo<2.2.2>octane

Base Information

Chemical Name:(+/-)-4-tert-butyl-3-cyano-1-(4-trimethylsilaethynylphenyl)-2,6,7-trioxabicyclo<2.2.2>octane
CAS No.:114096-09-2
Molecular Formula:C₂₁H₂₇NO₃Si
Molecular Weight:369.536
Hs Code.:

Synonyms:(+/-)-4-tert-butyl-3-cyano-1-(4-trimethylsilaethynylphenyl)-2,6,7-trioxabicyclo<2.2.2>octane

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Chemical Property of (+/-)-4-tert-butyl-3-cyano-1-(4-trimethylsilaethynylphenyl)-2,6,7-trioxabicyclo<2.2.2>octane

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Technology Process of (+/-)-4-tert-butyl-3-cyano-1-(4-trimethylsilaethynylphenyl)-2,6,7-trioxabicyclo<2.2.2>octane

There total 4 articles about (+/-)-4-tert-butyl-3-cyano-1-(4-trimethylsilaethynylphenyl)-2,6,7-trioxabicyclo<2.2.2>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 114096-08-1
(+/-)-4-tert-butyl-3-cyano-1-(4-iodophenyl)-2,6,7-trioxabicyclo<2.2.2>octane

: 1066-54-2
trimethylsilylacetylene

: 114096-09-2
(+/-)-4-tert-butyl-3-cyano-1-(4-trimethylsilaethynylphenyl)-2,6,7-trioxabicyclo<2.2.2>octane

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In diethylamine; at 25 ℃;
DOI:10.1021/jm00401a002

Reference yield:

: 99250-47-2
3-t-butyl-3-hydroxymethyl-oxetane

: 114096-09-2
(+/-)-4-tert-butyl-3-cyano-1-(4-trimethylsilaethynylphenyl)-2,6,7-trioxabicyclo<2.2.2>octane

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / pyridinium chlorochromate / CH₂Cl₂

2: 90 percent / NaCN / diethyl ether; H₂O

3: 58 percent / BF₃*Et₂O / CH₂Cl₂ / -70 °C

4: 99 percent / CuI, (Ph₃P)2PdCl₂ / diethylamine / 25 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron trifluoride diethyl etherate; sodium cyanide; pyridinium chlorochromate; In diethyl ether; dichloromethane; water; diethylamine;
DOI:10.1021/jm00401a002

Reference yield:

: 107829-98-1
3-t-butyl-3-formyl-oxetane

: 114096-09-2
(+/-)-4-tert-butyl-3-cyano-1-(4-trimethylsilaethynylphenyl)-2,6,7-trioxabicyclo<2.2.2>octane

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaCN / diethyl ether; H₂O

2: 58 percent / BF₃*Et₂O / CH₂Cl₂ / -70 °C

3: 99 percent / CuI, (Ph₃P)2PdCl₂ / diethylamine / 25 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron trifluoride diethyl etherate; sodium cyanide; In diethyl ether; dichloromethane; water; diethylamine;
DOI:10.1021/jm00401a002