Z-Asp(OtBu)-Val-Gly-Val-NH₂

Base Information

• Chemical Name: Z-Asp(OtBu)-Val-Gly-Val-NH₂
• CAS No.: 147424-47-3
• Molecular Formula: C₂₈H₄₃N₅O₈
• Molecular Weight: 577.678
• Mol file: 147424-47-3.mol

Synonyms:Z-Asp(OtBu)-Val-Gly-Val-NH₂

Chemical Property of Z-Asp(OtBu)-Val-Gly-Val-NH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-Asp(OtBu)-Val-Gly-Val-NH₂

There total 6 articles about Z-Asp(OtBu)-Val-Gly-Val-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester (41446-22-4) + Val-Gly-Val-NH2 (1026489-19-9) → Z-Asp(OtBu)-Val-Gly-Val-NH2 (147424-47-3)

Guidance literature:

With N-methylmorpholine hydrochloride; In N,N-dimethyl-formamide; at -10 - 0 ℃; for 4h;

DOI:10.1016/0223-5234(92)90113-F

Reference yield:

L-valinamide (4540-60-7,20108-78-5) → Z-Asp(OtBu)-Val-Gly-Val-NH2 (147424-47-3)

Guidance literature:

Multi-step reaction with 5 steps

1: N,N'-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C

2: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

3: 75 percent / N,N'-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C

4: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

5: 76 percent / N-methylmorpholine hydrochloride / dimethylformamide / 4 h / -10 - 0 °C

With hydrogen; N-methylmorpholine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/0223-5234(92)90113-F

Reference yield:

H-Gly-Val-NH2 (89315-03-7) → Z-Asp(OtBu)-Val-Gly-Val-NH2 (147424-47-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / N,N'-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C

2: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

3: 76 percent / N-methylmorpholine hydrochloride / dimethylformamide / 4 h / -10 - 0 °C

With hydrogen; N-methylmorpholine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/0223-5234(92)90113-F

upstream raw materials:

(S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester

Val-Gly-Val-NH₂

L-valinamide

H-Gly-Val-NH₂

Downstream raw materials:

C₄₆H₆₈N₈O₁₂