3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

Base Information

Chemical Name:3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate
CAS No.:936355-54-3
Molecular Formula:C₃₃H₃₂N₂O₆
Molecular Weight:552.627
Hs Code.:

Synonyms:3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

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Chemical Property of 3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

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Technology Process of 3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

There total 9 articles about 3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 936355-43-0
2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid

: 936355-48-5
2,4-dihydroxy-2-methyl-1-phenylbutan-1-one

: 936355-54-3
3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol070593j

Reference yield:

: 936355-47-4
4-(tert-butyldimethylsilyloxy)2-hydroxy-2-methyl-1-phenylbutan-1-one

: 936355-54-3
3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

2: 79 percent / DCC; DMAP / tetrahydrofuran; diethyl ether

With dmap; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol070593j

Reference yield:

: 936355-38-3
tert-butyl 3-(2,2-diphenylcyclopropyl)-3-oxopropanoate

: 936355-54-3
3-hydroxy-3-methyl-4-oxo-4-phenylbutyl-2-(6-(2,2-diphenylcyclopropyl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium ethoxide / ethanol / 110 °C

2: 2.3 g / chloroacetic acid / ethanol; H₂O / 24 h / 110 °C

3: 19 percent / potassium carbonate / dimethylsulfoxide / 24 h / 20 °C

4: 89 percent / potassium carbonate / acetone / 20 °C

5: 100 percent / aq. NaOH / methanol / 20 °C

6: 79 percent / DCC; DMAP / tetrahydrofuran; diethyl ether

With dmap; sodium hydroxide; sodium ethanolate; potassium carbonate; chloroacetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; dimethyl sulfoxide; acetone;
DOI:10.1021/ol070593j