Technology Process of 14-benzoylandrographolide-19-oic acid
There total 5 articles about 14-benzoylandrographolide-19-oic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
aq. phosphate buffer; methylbutane; dimethyl sulfoxide; tert-butyl alcohol;
at 0 - 20 ℃;
for 48.5h;
DOI:10.1016/j.bmcl.2013.04.010
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluene-4-sulfonic acid / toluene; dimethyl sulfoxide / 1.5 h / 80 °C
2: triethylamine; dmap / dichloromethane / 4 h / 20 °C / Reflux
3: acetic acid / water / 1 h / 20 °C
4: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetra-(n-butyl)ammonium iodide; N-chloro-succinimide / dichloromethane / 9 h / 0 °C / pH Ca.7
5: dimethyl sulfoxide; methylbutane; tert-butyl alcohol; aq. phosphate buffer / 48.5 h / 0 - 20 °C
With
dmap; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; acetic acid; triethylamine;
In
aq. phosphate buffer; methylbutane; dichloromethane; water; dimethyl sulfoxide; toluene; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2013.04.010
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine; dmap / dichloromethane / 4 h / 20 °C / Reflux
2: acetic acid / water / 1 h / 20 °C
3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetra-(n-butyl)ammonium iodide; N-chloro-succinimide / dichloromethane / 9 h / 0 °C / pH Ca.7
4: dimethyl sulfoxide; methylbutane; tert-butyl alcohol; aq. phosphate buffer / 48.5 h / 0 - 20 °C
With
dmap; N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetra-(n-butyl)ammonium iodide; acetic acid; triethylamine;
In
aq. phosphate buffer; methylbutane; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2013.04.010
