ethyl (2E)-3-[4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate

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Chemical Name:ethyl (2E)-3-[4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate
CAS No.:871553-44-5
Molecular Formula:C₁₇H₁₅N₅O₄
Molecular Weight:353.337
Hs Code.:

Synonyms:ethyl (2E)-3-[4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate

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Chemical Property of ethyl (2E)-3-[4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate

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Technology Process of ethyl (2E)-3-[4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate

There total 7 articles about ethyl (2E)-3-[4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 871553-42-3
4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde

: 871553-44-5
ethyl (2E)-3-[4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With lithium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde; In tetrahydrofuran; for 2h; Heating / reflux;

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 871553-12-7
ethyl 4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

: 871553-44-5
ethyl (2E)-3-[4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 20 °C

2.1: Dess-Martin periodane / tetrahydrofuran; dichloromethane / 5 h / 20 °C

3.1: lithium hydride / tetrahydrofuran / 0.5 h / 20 °C

3.2: 2 h / Heating / reflux

3.3: 20 °C

With lithium hydride; diisobutylaluminium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 871553-17-2
ethyl 5-formyl-4-(4-nitrophenyl)-1H-pyrrole-3-carboxylate

: 871553-44-5
ethyl (2E)-3-[4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; hydroxylamine hydrochloride / 2 h / 20 °C

1.2: 17 h / 80 °C

2.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.25 h / 20 °C

2.2: 17 h / 20 - 80 °C

2.3: 20 °C

3.1: 19 h / 20 - 195 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 20 °C

5.1: Dess-Martin periodane / tetrahydrofuran; dichloromethane / 5 h / 20 °C

6.1: lithium hydride / tetrahydrofuran / 0.5 h / 20 °C

6.2: 2 h / Heating / reflux

6.3: 20 °C

With pyridine; hydroxylamine hydrochloride; lithium hydride; sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; toluene;