(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one

Base Information

Chemical Name:(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one
CAS No.:1351192-04-5
Molecular Formula:C₁₇H₂₄FN₃O₃S
Molecular Weight:369.46
Hs Code.:

Synonyms:(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one

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Chemical Property of (S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one

Chemical Property:

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Technology Process of (S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one

There total 6 articles about (S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1365998-48-6
(S)-tert-butyl 3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxo-1,4'-bipiperidin-1'-carboxylate

: 1351192-04-5
(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 2640-58-6
Nα-benzyloxycarbonyl-L-ornithine

: 1351192-04-5
(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; tetrahydrofuran / 1 h

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

4.1: sodium carbonate / dimethyl sulfoxide / 120 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 851120-59-7
(S)-2-(benzyloxycarbonylamino)-5-(1-(tertbutoxycarbonyl)piperidin-4-ylamino)pentanoic acid

: 1351192-04-5
(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h

3: sodium carbonate / dimethyl sulfoxide / 120 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;