[(S)-1-((S)-2-{(S)-1-[(5-Chloro-benzooxazol-2-yl)-hydroxy-methyl]-2-methyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [(S)-1-((S)-2-{(S)-1-[(5-Chloro-benzooxazol-2-yl)-hydroxy-methyl]-2-methyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester
• CAS No.: 1025998-99-5
• Molecular Formula: C₃₀H₃₇ClN₄O₆
• Molecular Weight: 585.1

Synonyms:[(S)-1-((S)-2-{(S)-1-[(5-Chloro-benzooxazol-2-yl)-hydroxy-methyl]-2-methyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester

Chemical Property of [(S)-1-((S)-2-{(S)-1-[(5-Chloro-benzooxazol-2-yl)-hydroxy-methyl]-2-methyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester

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Technology Process of [(S)-1-((S)-2-{(S)-1-[(5-Chloro-benzooxazol-2-yl)-hydroxy-methyl]-2-methyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester

There total 3 articles about [(S)-1-((S)-2-{(S)-1-[(5-Chloro-benzooxazol-2-yl)-hydroxy-methyl]-2-methyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Benzyloxycarbonyl-L-valyl-L-prolyl-L-valinal (95501-78-3) → [(S)-1-((S)-2-{(S)-1-[(5-Chloro-benzooxazol-2-yl)-hydroxy-methyl]-2-methyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester (1025998-99-5)

Guidance literature:

Multi-step reaction with 3 steps

1: water / tetrahydrofuran / 4.5 h / Ambient temperature

2: acetyl chloride / CHCl₃ / 16 h / Ambient temperature

3: ethanol / 4 h / 60 °C

With water; acetyl chloride; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1021/jm00020a011

Reference yield:

<(benzyloxycarbonyl)-L-valyl>-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide → [(S)-1-((S)-2-{(S)-1-[(5-Chloro-benzooxazol-2-yl)-hydroxy-methyl]-2-methyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester (1025998-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetyl chloride / CHCl₃ / 16 h / Ambient temperature

2: ethanol / 4 h / 60 °C

With acetyl chloride; In ethanol; chloroform;

DOI:10.1021/jm00020a011

Reference yield:

(S)-3-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-2-hydroxy-4-methyl-pentanimidic acid ethyl ester; hydrochloride + 2-hydroxy-5-chloro-aniline (95-85-2) → [(S)-1-((S)-2-{(S)-1-[(5-Chloro-benzooxazol-2-yl)-hydroxy-methyl]-2-methyl-propylcarbamoyl}-pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester (1025998-99-5)

Guidance literature:

In ethanol; at 60 ℃; for 4h;

DOI:10.1021/jm00020a011

upstream raw materials:

2-hydroxy-5-chloro-aniline

N-Benzyloxycarbonyl-L-valyl-L-prolyl-L-valinal

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