N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide

Base Information

Chemical Name:N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide
CAS No.:1398111-32-4
Molecular Formula:C₁₅H₁₄FN₅OS
Molecular Weight:331.373
Hs Code.:

Synonyms:N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide

Suppliers and Price of N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide

There total 4 articles about N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₂FN₅O₃S

: 1398111-32-4
N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide

Guidance literature:: With methoxybenzene; trifluoroacetic acid; at 0 ℃; for 1h;
DOI:10.1016/j.bmc.2012.07.032

Reference yield:

: 1125633-05-7
tert-butyl [2-fluoro-5-(methylamino)phenyl]carbamate

: 1398111-32-4
N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 19 h / 60 °C

2: 10% Pd/C; hydrogen / tetrahydrofuran; ethanol / 22 h / 20 °C / 2280.15 Torr

3: bromine / acetic acid / 1.67 h / 10 - 20 °C

4: pyridine / 1 h / 0 - 20 °C

5: methoxybenzene; trifluoroacetic acid / 1 h / 0 °C

With pyridine; 10% Pd/C; hydrogen; bromine; methoxybenzene; trifluoroacetic acid; In tetrahydrofuran; ethanol; acetic acid; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2012.07.032

Reference yield:

: 1125633-06-8
tert-butyl [2-fluoro-5-(methylamino)phenyl]carbamate

: 1398111-32-4
N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 1.5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: dimethyl sulfoxide / 19 h / 60 °C

3.1: 10% Pd/C; hydrogen / tetrahydrofuran; ethanol / 22 h / 20 °C / 2280.15 Torr

4.1: bromine / acetic acid / 1.67 h / 10 - 20 °C

5.1: pyridine / 1 h / 0 - 20 °C

6.1: methoxybenzene; trifluoroacetic acid / 1 h / 0 °C

With pyridine; dimethylsulfide borane complex; 10% Pd/C; hydrogen; bromine; methoxybenzene; trifluoroacetic acid; In tetrahydrofuran; ethanol; acetic acid; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2012.07.032