4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine

Base Information

Chemical Name:4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine
CAS No.:220953-42-4
Molecular Formula:C₂₁H₃₁BrN₆O₂
Molecular Weight:479.42
Hs Code.:

Synonyms:4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine

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Chemical Property of 4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine

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Technology Process of 4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine

There total 6 articles about 4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 220953-41-3
4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylcarboxamido)butylamino>-2-methyl-5-nitropyrimidin-4-amine

: 220953-42-4
4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine

Guidance literature:: With borane-THF; In tetrahydrofuran; for 14h;
DOI:10.1021/jm980224g

Reference yield:

: 21691-43-0
(R,S)-2-(N-benzyloxycarbonylamino)pentanoic acid

: 220953-42-4
4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / HOBt, Et₃N, DCC / tetrahydrofuran / 12 h / Ambient temperature

2: 77 percent / H₂ / 5 percent Pd/C / ethanol / 14 h / 2585.74 Torr

3: Et₃N / ethanol / 1 h / Ambient temperature

4: dimethylformamide / 60 °C

5: 62 percent / BH₃*THF / tetrahydrofuran / 14 h

With borane-THF; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980224g

Reference yield:

: 197803-18-2
N-CBz-D,L-norvaline dimethylamide

: 220953-42-4
4-N-<2-bromo-4-(1-methylethyl)phenyl>-6-<1-(N,N-dimethylamino)-2-pentylamino>-2-methyl-5-nitropyrimidine-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / H₂ / 5 percent Pd/C / ethanol / 14 h / 2585.74 Torr

2: Et₃N / ethanol / 1 h / Ambient temperature

3: dimethylformamide / 60 °C

4: 62 percent / BH₃*THF / tetrahydrofuran / 14 h

With borane-THF; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm980224g