Technology Process of (1S)-1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-{6-[(4-ethylphenyl)(hydroxy)methyl]pyridin-2-yl}-D-glucitol
There total 4 articles about (1S)-1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-{6-[(4-ethylphenyl)(hydroxy)methyl]pyridin-2-yl}-D-glucitol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-ethyl-1-iodobenzene;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at -30 ℃;
for 2h;
C40H39NO6;
In
tetrahydrofuran;
at 20 ℃;
for 2.5h;
With
water; ammonium chloride;
In
tetrahydrofuran;
DOI:10.1016/j.bmc.2012.03.051
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.42 h / -78 °C
1.2: 3.5 h / -78 °C
2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 0 - 20 °C
3.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / methanol; dimethyl sulfoxide / 24 h / 70 °C
3.2: 2 h / 20 °C
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C
5.1: diisobutylaluminium hydride / hexane; dichloromethane / 3 h / 0 °C
6.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -30 °C
6.2: 2.5 h / 20 °C
With
triethylsilane; n-butyllithium; 1,3-bis-(diphenylphosphino)propane; isopropylmagnesium chloride; palladium diacetate; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.051
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C
2.1: diisobutylaluminium hydride / hexane; dichloromethane / 3 h / 0 °C
3.1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / -30 °C
3.2: 2.5 h / 20 °C
With
isopropylmagnesium chloride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.051
