(4R)-3-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)thiazolidine-4-carboxylic acid

Base Information

Chemical Name:(4R)-3-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)thiazolidine-4-carboxylic acid
CAS No.:637032-06-5
Molecular Formula:C₁₅H₁₉NO₅S
Molecular Weight:325.386
Hs Code.:

Synonyms:(4R)-3-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)thiazolidine-4-carboxylic acid

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Chemical Property of (4R)-3-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)thiazolidine-4-carboxylic acid

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Technology Process of (4R)-3-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)thiazolidine-4-carboxylic acid

There total 2 articles about (4R)-3-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)thiazolidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 222404-24-2,69588-11-0
(2RS,4R)-2-(4-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid

: 24424-99-5
di-tert-butyl dicarbonate

: 637032-06-5
(4R)-3-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)thiazolidine-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2005.06.032

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 637032-06-5
(4R)-3-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)thiazolidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 20 °C

2: 100 percent / aq. NaOH / dioxane

With sodium hydroxide; In 1,4-dioxane; ethanol;
DOI:10.1016/j.bmcl.2005.06.032

Reference yield:

: 637032-06-5
(4R)-3-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)thiazolidine-4-carboxylic acid

: (R)-2-(4-Hydroxy-phenyl)-thiazolidine-4-carboxylic acid octadecylamide

Guidance literature:: Multi-step reaction with 2 steps

1: EDC; HOBt / CH₂Cl₂

2: TFA / CH₂Cl₂

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2005.06.032