1-(4-chlorobenzyl)-2-ethylcyclopropylamine

Base Information

• Chemical Name: 1-(4-chlorobenzyl)-2-ethylcyclopropylamine
• CAS No.: 929907-26-6
• Molecular Formula: C₁₂H₁₆ClN
• Molecular Weight: 209.719
• Mol file: 929907-26-6.mol

Synonyms:1-(4-chlorobenzyl)-2-ethylcyclopropylamine

Chemical Property of 1-(4-chlorobenzyl)-2-ethylcyclopropylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-(4-chlorobenzyl)-2-ethylcyclopropylamine

There total 1 articles about 1-(4-chlorobenzyl)-2-ethylcyclopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

n-butyl magnesium bromide (693-03-8) + p-chlorobenzyl cyanide (140-53-4) → 1-(4-chlorobenzyl)-2-ethylcyclopropylamine (929907-26-6)

Guidance literature:

With titanium(IV) isopropylate; boron trifluoride diethyl etherate; In diethyl ether; at 25 ℃; for 0.75h;

DOI:10.1055/s-2006-958927

Reference yield: 64.0%

1-(4-chlorobenzyl)-2-ethylcyclopropylamine (929907-26-6) + orthoformic acid triethyl ester (122-51-0) → N-[1-(4-chlorobenzyl)-2-ethylcyclopropyl]formamide (929907-28-8)

Guidance literature:

Heating;

DOI:10.1055/s-2006-958927

Reference yield:

1-(4-chlorobenzyl)-2-ethylcyclopropylamine (929907-26-6) → 1-(4-chlorobenzyl)-2-ethylcyclopropylisonitrile (929907-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / Heating

2: 88 percent / phosgene; triethylamine / toluene / 0 - 40 °C

With phosgene; triethylamine; In toluene;

DOI:10.1055/s-2006-958927

upstream raw materials:

n-butyl magnesium bromide

p-chlorobenzyl cyanide

Downstream raw materials:

N-[1-(4-chlorobenzyl)-2-ethylcyclopropyl]formamide

1-(4-chlorobenzyl)-2-ethylcyclopropylisonitrile

Refernces