Technology Process of 6-bromo-3-isopropoxy-2-methoxy-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide
There total 3 articles about 6-bromo-3-isopropoxy-2-methoxy-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-bromo-3-isopropoxy-2-methoxybenzoic acid;
With
oxalyl dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
for 2h;
N-methyl-6,7-(methylenedioxy)-1-naphthylamine;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 3h;
DOI:10.3987/COM-02-S35
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 89 percent / sodium phosphate dihydrate; hydrogen peroxide; sodium chlorite / acetonitrile; H2O / 8 h / 10 °C
2.1: 80 percent / NaOH; dibromodimethylhydantoin / H2O / 0.67 h / 20 °C
3.1: oxalyl chloride / dimethylformamide; CH2Cl2 / 2 h
3.2: 64 percent / NEt3 / CH2Cl2 / 3 h / 20 °C
With
sodium hydroxide; sodium chlorite; disodium hydrogenphosphate; oxalyl dichloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dihydrogen peroxide;
In
dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.3987/COM-02-S35
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 80 percent / NaOH; dibromodimethylhydantoin / H2O / 0.67 h / 20 °C
2.1: oxalyl chloride / dimethylformamide; CH2Cl2 / 2 h
2.2: 64 percent / NEt3 / CH2Cl2 / 3 h / 20 °C
With
sodium hydroxide; oxalyl dichloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione;
In
dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-02-S35