(3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide

Base Information

Chemical Name:(3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide
CAS No.:202859-91-4
Molecular Formula:C₂₆H₄₉NO₆Si₂
Molecular Weight:527.849
Hs Code.:

Synonyms:(3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide

Suppliers and Price of (3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide

There total 7 articles about (3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 99440-92-3
Me₂AlN(Me)OMe

: 202859-87-8
(4R,6R,7R)-6-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-methoxy-phenyl-silanyloxy)-7-methyl-oxepan-2-one

: 202859-91-4
(3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide

Guidance literature:: In dichloromethane; for 12h; Ambient temperature;

Reference yield:

: 191410-00-1
(2R,3R,5R)-3-tert-butyldimethylsilyloxy-2-methyl-5-(1-methylethenyl)cyclohexanone

: 202859-91-4
(3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: KIO₄, OsO₄ / tetrahydrofuran; H₂O / 12 h

2: 70 percent / MCPBA / CH₂Cl₂ / 144 h / Ambient temperature

3: 78 percent / acetone; H₂O; various solvent(s) / 35 °C / PLE (EC 3.1.1.1)

4: 98 percent / Et₃N, DMF / CH₂Cl₂ / 6 h / Ambient temperature

5: 61 percent / CH₂Cl₂ / 12 h / Ambient temperature

With osmium(VIII) oxide; potassium metaperiodate; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; acetone;

Reference yield:

: 191410-02-3
Acetic acid (1R,3R,4R)-3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-5-oxo-cyclohexyl ester

: 202859-91-4
(3R,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-methoxy-phenyl-silanyloxy)-6-hydroxy-heptanoic acid methoxy-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / MCPBA / CH₂Cl₂ / 48 h / Ambient temperature

2: 78 percent / acetone; H₂O; various solvent(s) / 35 °C / PLE (EC 3.1.1.1)

3: 98 percent / Et₃N, DMF / CH₂Cl₂ / 6 h / Ambient temperature

4: 61 percent / CH₂Cl₂ / 12 h / Ambient temperature

With triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; acetone;