2-(4-(6-aminopyrimidin-4-ylamino)-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile

Base Information

Chemical Name:2-(4-(6-aminopyrimidin-4-ylamino)-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile
CAS No.:1428653-85-3
Molecular Formula:C₁₇H₁₁FN₈
Molecular Weight:346.326
Hs Code.:

Synonyms:2-(4-(6-aminopyrimidin-4-ylamino)-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile

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Chemical Property of 2-(4-(6-aminopyrimidin-4-ylamino)-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile

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Technology Process of 2-(4-(6-aminopyrimidin-4-ylamino)-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile

There total 4 articles about 2-(4-(6-aminopyrimidin-4-ylamino)-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 2434-56-2
4,6-diaminopyrimidine

: 1428653-97-7
2-(4-bromo-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile

: 1428653-85-3
2-(4-(6-aminopyrimidin-4-ylamino)-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1121-86-4
1-Fluoro-3-iodobenzene

: 1428653-85-3
2-(4-(6-aminopyrimidin-4-ylamino)-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: iron(III) chloride / ethanol / 60 °C

3.1: N,N-dimethyl-formamide / 3 h / 150 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

With iron(III) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 146137-72-6
6-fluoro-2-iodobenzaldehyde

: 1428653-85-3
2-(4-(6-aminopyrimidin-4-ylamino)-3H-imidazo[4,5-c]pyridin-2-yl)-3-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: iron(III) chloride / ethanol / 60 °C

2: N,N-dimethyl-formamide / 3 h / 150 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

With iron(III) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;