N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]furan-2-carboxamide

Base Information

Chemical Name:N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]furan-2-carboxamide
CAS No.:1346159-44-1
Molecular Formula:C₂₁H₂₄N₄O₄
Molecular Weight:396.446
Hs Code.:

Synonyms:N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]furan-2-carboxamide

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Chemical Property of N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]furan-2-carboxamide

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Technology Process of N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]furan-2-carboxamide

There total 5 articles about N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₅N₃O₄

: 1346159-44-1
N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]furan-2-carboxamide

Guidance literature:: C₂₂H₂₅N₃O₄; With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water; at 0 ℃; pH=6;
DOI:10.1016/j.ejmech.2011.09.018

Reference yield:

: C₁₅H₁₄N₂O₃

: 1346159-44-1
N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]furan-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

3.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 3 h / 20 °C

3.2: 0 °C / pH 6

With hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.018

Reference yield:

: 2527-96-0
methyl 5-methyl-2-furancarboxylate

: 1346159-44-1
N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-5-[(2-methyl-1H-benzimidazol-1-yl)methyl]furan-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide; dibenzoyl peroxide / tetrachloromethane / 12 h / Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

5.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 3 h / 20 °C

5.2: 0 °C / pH 6

With N-chloro-succinimide; hydroxylamine hydrochloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.018