Technology Process of ethyl 4‐oxo‐2-(1-(4-(trifluoromethoxy)benzyl)-1H-pyrazol-4-yl)‐1,4‐dihydroquinoline-3-carboxylate
There total 9 articles about ethyl 4‐oxo‐2-(1-(4-(trifluoromethoxy)benzyl)-1H-pyrazol-4-yl)‐1,4‐dihydroquinoline-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
formic acid; water;
In
N,N-dimethyl-formamide;
at 140 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trichlorophosphate / 1,4-dioxane / 1 h / 120 °C
2: 3-chloro-benzenecarboperoxoic acid / chloroform / 4 h / 20 °C
3: phosphorus(V) oxybromide / chloroform / 1 h / 20 °C
4: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere
5: water; formic acid / N,N-dimethyl-formamide / 4 h / 140 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; formic acid; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; phosphorus(V) oxybromide;
In
1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.8b00371
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate / N,N-dimethyl-formamide / 90 °C
2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere
3: water; formic acid / N,N-dimethyl-formamide / 4 h / 140 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; formic acid; water; potassium carbonate; caesium carbonate;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.8b00371