N₄-acetyl-2'-O-pivaloyloxymethyl-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Base Information

• Chemical Name: N₄-acetyl-2'-O-pivaloyloxymethyl-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)
• CAS No.: 1097131-18-4
• Molecular Formula: C₄₇H₆₀N₅O₁₁P
• Molecular Weight: 901.994

Synonyms:N₄-acetyl-2'-O-pivaloyloxymethyl-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Chemical Property of N₄-acetyl-2'-O-pivaloyloxymethyl-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

Chemical Property:

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Technology Process of N₄-acetyl-2'-O-pivaloyloxymethyl-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

There total 1 articles about N₄-acetyl-2'-O-pivaloyloxymethyl-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N4-acetyl-2'-O-pivaloyloxymethyl-5'-O-(4,4'-dimethoxytrityl)cytidine (1097131-01-5) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → N4-acetyl-2'-O-pivaloyloxymethyl-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) (1097131-18-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.200801392

upstream raw materials:

N₄-acetyl-2'-O-pivaloyloxymethyl-5'-O-(4,4'-dimethoxytrityl)cytidine

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

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