1-(3-{[7-(benzyloxy)-6-methoxyquinazolin-4-yl]oxy}-2-fluoro-6-nitrophenyl)acetone

Base Information

Chemical Name:1-(3-{[7-(benzyloxy)-6-methoxyquinazolin-4-yl]oxy}-2-fluoro-6-nitrophenyl)acetone
CAS No.:1022112-47-5
Molecular Formula:C₂₅H₂₀FN₃O₆
Molecular Weight:477.449
Hs Code.:

Synonyms:1-(3-{[7-(benzyloxy)-6-methoxyquinazolin-4-yl]oxy}-2-fluoro-6-nitrophenyl)acetone

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Chemical Property of 1-(3-{[7-(benzyloxy)-6-methoxyquinazolin-4-yl]oxy}-2-fluoro-6-nitrophenyl)acetone

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Technology Process of 1-(3-{[7-(benzyloxy)-6-methoxyquinazolin-4-yl]oxy}-2-fluoro-6-nitrophenyl)acetone

There total 1 articles about 1-(3-{[7-(benzyloxy)-6-methoxyquinazolin-4-yl]oxy}-2-fluoro-6-nitrophenyl)acetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 649736-31-2
1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one

: 162364-72-9
7-benzyloxy-4-chloro-6-methoxyquinazoline

: 1022112-47-5
1-(3-{[7-(benzyloxy)-6-methoxyquinazolin-4-yl]oxy}-2-fluoro-6-nitrophenyl)acetone

Guidance literature:: 1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one; With sodium hydroxide; In water; acetonitrile; at -5 ℃;

7-benzyloxy-4-chloro-6-methoxyquinazoline; In water; methoxybenzene; acetonitrile; at 80 ℃; for 21.25h;

Reference yield:

: 1022112-47-5
1-(3-{[7-(benzyloxy)-6-methoxyquinazolin-4-yl]oxy}-2-fluoro-6-nitrophenyl)acetone

: 574745-76-9
7-hydroxy-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinazoline

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; water; at 50 ℃; for 2.75h; under 3000.3 Torr; Product distribution / selectivity;