Technology Process of buprenorphine (PABA-PHBA) carbamate
There total 6 articles about buprenorphine (PABA-PHBA) carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethyl acetate;
at 20 ℃;
for 5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate / dichloromethane; toluene; water / 0.25 h / 0 - 20 °C
2: toluene / Reflux
3: hydrogen / palladium 10% on activated carbon / ethyl acetate; tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
4: dmap; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide; tetrahydrofuran
5: hydrogen / palladium 10% on activated carbon / ethyl acetate; tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
With
dmap; hydrogen; sodium hydrogencarbonate; dicyclohexyl-carbodiimide;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
1: Schotten-Baumann Reaction;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine / dichloromethane; toluene / 2 h / 0 - 20 °C / Inert atmosphere
2: toluene / Reflux
3: hydrogen / palladium 10% on activated carbon / ethyl acetate; tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
4: dmap; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide; tetrahydrofuran
5: hydrogen / palladium 10% on activated carbon / ethyl acetate; tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
With
pyridine; dmap; hydrogen; dicyclohexyl-carbodiimide;
palladium 10% on activated carbon;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
1: Schotten-Baumann Reaction;
