[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy][(2R,3R)-3-(phenylmethoxy)(tetrahydro-2H-pyran-2-yl)]methane

Base Information

Chemical Name:[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy][(2R,3R)-3-(phenylmethoxy)(tetrahydro-2H-pyran-2-yl)]methane
CAS No.:864719-81-3
Molecular Formula:C₂₀H₃₀O₅
Molecular Weight:350.455
Hs Code.:

Synonyms:[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy][(2R,3R)-3-(phenylmethoxy)(tetrahydro-2H-pyran-2-yl)]methane

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Chemical Property of [2-(tetrahydro-2H-pyran-2-yloxy)ethoxy][(2R,3R)-3-(phenylmethoxy)(tetrahydro-2H-pyran-2-yl)]methane

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Technology Process of [2-(tetrahydro-2H-pyran-2-yloxy)ethoxy][(2R,3R)-3-(phenylmethoxy)(tetrahydro-2H-pyran-2-yl)]methane

There total 3 articles about [2-(tetrahydro-2H-pyran-2-yloxy)ethoxy][(2R,3R)-3-(phenylmethoxy)(tetrahydro-2H-pyran-2-yl)]methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 864719-80-2
[(2R,3R)-3-(phenylmethoxy)-tetrahydro-2H-pyran-2-yl]methan-1-ol

: 5631-96-9
2-(2-chloroethoxy)-tetrahydro-2H-pyrane

: 864719-81-3
[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy][(2R,3R)-3-(phenylmethoxy)(tetrahydro-2H-pyran-2-yl)]methane

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; at 65 ℃; for 24h;
DOI:10.1016/j.tet.2005.06.034

Reference yield:

: (4aR,8aR)-2-Phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine

: 864719-81-3
[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy][(2R,3R)-3-(phenylmethoxy)(tetrahydro-2H-pyran-2-yl)]methane

Guidance literature:: Multi-step reaction with 2 steps

1: 3.03 g / DIBAL-H / CH₂Cl₂; hexane / 0.5 h / 0 °C

2: 92 percent / tetrabutylammonium hydrogen sulphate; aq. NaOH / 24 h / 65 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; diisobutylaluminium hydride; In hexane; dichloromethane;
DOI:10.1016/j.tet.2005.06.034

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 864719-81-3
[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy][(2R,3R)-3-(phenylmethoxy)(tetrahydro-2H-pyran-2-yl)]methane

Guidance literature:: Multi-step reaction with 3 steps

1: camphorsulfonic acid / CH₂Cl₂ / 2 h / 20 °C

2: 3.03 g / DIBAL-H / CH₂Cl₂; hexane / 0.5 h / 0 °C

3: 92 percent / tetrabutylammonium hydrogen sulphate; aq. NaOH / 24 h / 65 °C

With sodium hydroxide; camphor-10-sulfonic acid; tetra(n-butyl)ammonium hydrogensulfate; diisobutylaluminium hydride; In hexane; dichloromethane;
DOI:10.1016/j.tet.2005.06.034