diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine

Base Information

• Chemical Name: diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine
• CAS No.: 1338605-37-0
• Molecular Formula: C₅₂H₅₂N₅O₆P
• Molecular Weight: 873.989

Synonyms:diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine

Chemical Property of diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine

Chemical Property:

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Technology Process of diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine

There total 4 articles about diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N₆-(4-monomethoxytrityl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethyl (p-toluenesulfonyloxymethane)phosphonate (31618-90-3) + (R)-9-[3-trityloxy-2-hydroxypropyl]-N6-(4-monomethoxytrityl)adenine (1338605-36-9) → diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)adenine (1338605-37-0)

Guidance literature:

With sodium t-butanolate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) → diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)adenine (1338605-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 6 h / 100 °C

2: pyridine; trimethylsilyl bromide / 0.25 h

3: sodium t-butanolate / N,N-dimethyl-formamide / 80 °C

With pyridine; trimethylsilyl bromide; sodium hydride; sodium t-butanolate; In N,N-dimethyl-formamide;

Reference yield:

(R)-(+)-trityl glycidyl ether (65291-30-7) → diethyl (R)-9-[3-trityloxy-2-(phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)adenine (1338605-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 6 h / 100 °C

2: pyridine; trimethylsilyl bromide / 0.25 h

3: sodium t-butanolate / N,N-dimethyl-formamide / 80 °C

With pyridine; trimethylsilyl bromide; sodium hydride; sodium t-butanolate; In N,N-dimethyl-formamide;

upstream raw materials:

diethyl (p-toluenesulfonyloxymethane)phosphonate

(R)-9-[3-trityloxy-2-hydroxypropyl]-N₆-(4-monomethoxytrityl)adenine

adenine

(R)-(+)-trityl glycidyl ether

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