(R)-1-(butylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

Base Information

Chemical Name:(R)-1-(butylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide
CAS No.:910481-95-7
Molecular Formula:C₁₈H₂₈N₂O₄S
Molecular Weight:368.497
Hs Code.:

Synonyms:(R)-1-(butylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

Suppliers and Price of (R)-1-(butylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(butylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

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Technology Process of (R)-1-(butylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

There total 2 articles about (R)-1-(butylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

: 910481-82-2
(R)-1-(butylsulfonyl)pyrrolidine-2-carboxylic acid

: (S)-(-)-2-amino-3-phenyl-1-propanol hydrochloride salt

: 910481-95-7
(R)-1-(butylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/jm050849w

Reference yield:

: 344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7
D-Prolin

: 910481-95-7
(R)-1-(butylsulfonyl)-N-((S)-1-hydroxy-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93.1 percent / aq. K₂CO₃ / tetrahydrofuran / 5 h / 50 °C

2: 79.2 percent / EDC; HOBT; NMM / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050849w