3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile

Base Information

• Chemical Name: 3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile
• CAS No.: 846601-44-3
• Molecular Formula: C₂₂H₂₇IN₂O₄
• Molecular Weight: 510.372
• Mol file: 846601-44-3.mol

Synonyms:3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile

Chemical Property of 3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile

There total 3 articles about 3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

3,4-dimethoxyphenylacetaldehyde (5703-21-9) + potassium cyanide (151-50-8) + [2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamine (846601-41-0) → 3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile (846601-44-3)

Guidance literature:

With sodium hydrogensulfite; In methanol; water; for 1h; Heating;

DOI:10.1007/s00706-004-0204-8

Reference yield:

N-methylhomoveratrylamine (3490-06-0) → 3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile (846601-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / F₃CCO₂Ag; I₂ / CH₂Cl₂ / 0.33 h / -5 °C

2: 76 percent / NaHSO₃ / H₂O; methanol / 1 h / Heating

With iodine; silver trifluoroacetate; sodium hydrogensulfite; In methanol; dichloromethane; water; 2: Strecker reaction;

DOI:10.1007/s00706-004-0204-8

Reference yield:

2-(3,4-dimethoxyphenyl)ethyl alcohol (7417-21-2) → 3-(3,4-dimethoxyphenyl)-2-{[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamino}propionitrile (846601-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / Dess-Martin periodinane / CH₂Cl₂

2: 76 percent / NaHSO₃ / H₂O; methanol / 1 h / Heating

With Dess-Martin periodane; sodium hydrogensulfite; In methanol; dichloromethane; water; 2: Strecker reaction;

DOI:10.1007/s00706-004-0204-8

upstream raw materials:

3,4-dimethoxyphenylacetaldehyde

potassium cyanide

[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]methylamine

N-methylhomoveratrylamine

Downstream raw materials:

laudanosine