(R)-5-chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one

Base Information

Chemical Name:(R)-5-chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one
CAS No.:1173523-52-8
Molecular Formula:C₁₈H₂₂ClN₃O₃
Molecular Weight:363.844
Hs Code.:

Synonyms:(R)-5-chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one

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Chemical Property of (R)-5-chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one

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Technology Process of (R)-5-chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one

There total 8 articles about (R)-5-chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1173523-44-8
(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one

: 1173523-52-8
(R)-5-chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one

Guidance literature:: (R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one; With boron tribromide; In dichloromethane; at 0 ℃; for 1h;

With water; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1021/jm900301y

Reference yield:

: 1428768-65-3
C₂₅H₂₈ClN₃O₃

: 1173523-52-8
(R)-5-chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃;
DOI:10.1016/j.bmcl.2013.02.009

Reference yield:

: 1270290-36-2,1198185-81-7
(R)-2-amino-2-cyclopropylethan-1-ol

: 1173523-52-8
(R)-5-chloro-1-(1-cyclopropyl-2-hydroxyethyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / dichloromethane; water / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 20 °C

3: trifluoroacetic acid / 20 °C

4: potassium iodide; potassium carbonate / acetonitrile / 18 h / 55 °C

5: toluene / 15.25 h / -78 - 55 °C

6: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 20 °C

7: boron tribromide / dichloromethane / -78 °C

With sodium hexamethyldisilazane; boron tribromide; sodium hydride; potassium carbonate; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2013.02.009