2-[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]propanoic acid

Base Information

Chemical Name:2-[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]propanoic acid
CAS No.:1257395-47-3
Molecular Formula:C₂₉H₂₆F₇NO₂
Molecular Weight:553.52
Hs Code.:

Synonyms:2-[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]propanoic acid

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Chemical Property of 2-[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]propanoic acid

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Technology Process of 2-[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]propanoic acid

There total 9 articles about 2-[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257395-47-3
2-[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / acetonitrile / 6 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 17 h / -78 - 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

4.1: triethylamine; magnesium chloride / acetonitrile / Inert atmosphere; Heating

4.2: 20 °C / Reflux; Inert atmosphere

5.1: 4-methyl-1,2,3-trifluorobenzene / Microwave irradiation; Inert atmosphere; Heating

6.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

7.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Microwave irradiation; Heating

8.1: water; sodium hydroxide / tetrahydrofuran; methanol / Microwave irradiation; Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; sodium hydroxide; magnesium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 4-methyl-1,2,3-trifluorobenzene; 5.1: Mannich reaction / 7.1: Suzuki coupling;
DOI:10.1021/ml200175q

Reference yield:

: 62969-42-0
3-benzyloxy-phenylacetic acid methyl ester

: 1257395-47-3
2-[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 17 h / -78 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h

3.1: triethylamine; magnesium chloride / acetonitrile / Inert atmosphere; Heating

3.2: 20 °C / Reflux; Inert atmosphere

4.1: 4-methyl-1,2,3-trifluorobenzene / Microwave irradiation; Inert atmosphere; Heating

5.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Microwave irradiation; Heating

7.1: water; sodium hydroxide / tetrahydrofuran; methanol / Microwave irradiation; Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; triethylamine; sodium hydroxide; magnesium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 4-methyl-1,2,3-trifluorobenzene; 4.1: Mannich reaction / 6.1: Suzuki coupling;
DOI:10.1021/ml200175q

Reference yield:

: C₂₃H₂₅F₄NO₃

: 1257395-47-3
2-[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Microwave irradiation; Heating

3: water; sodium hydroxide / tetrahydrofuran; methanol / Microwave irradiation; Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 2: Suzuki coupling;
DOI:10.1021/ml200175q