6-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)-hex-5-ynonitrile

Base Information

• Chemical Name: 6-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)-hex-5-ynonitrile
• CAS No.: 929880-44-4
• Molecular Formula: C₁₇H₁₅N₃O
• Molecular Weight: 277.326
• Mol file: 929880-44-4.mol

Synonyms:6-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)-hex-5-ynonitrile

Chemical Property of 6-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)-hex-5-ynonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)-hex-5-ynonitrile

There total 5 articles about 6-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)-hex-5-ynonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid 5-(5-cyano-pent-1-ynyl)-6-methyl-2-phenyl-pyrimidin-4-yl ester → 6-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)-hex-5-ynonitrile (929880-44-4)

Guidance literature:

With hydrazine; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.tet.2006.12.077

Reference yield:

acetic acid 5-iodo-6-methyl-2-phenyl-pyrimidin-4-yl ester (929880-36-4) → 6-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)-hex-5-ynonitrile (929880-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(I) iodide; diisopropylethylamine / dichlorobis(triphenylphosphine)-palladium / 24 h

2: hydrazine / tetrahydrofuran / 0 °C

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; hydrazine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1: Sonogashira coupling;

DOI:10.1016/j.tet.2006.12.077

Reference yield:

5-iodo-6-methyl-2-phenylpyrimidin-4-ol (83419-12-9) → 6-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)-hex-5-ynonitrile (929880-44-4)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(I) iodide; diisopropylethylamine / dichlorobis(triphenylphosphine)-palladium / 24 h

2: hydrazine / tetrahydrofuran / 0 °C

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; hydrazine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 2: Sonogashira coupling;

DOI:10.1016/j.tet.2006.12.077

upstream raw materials:

5-iodo-6-methyl-2-phenylpyrimidin-4-ol

acetic acid 5-iodo-6-methyl-2-phenyl-pyrimidin-4-yl ester

benzamidin

6-methyl-2-phenylpyrimidin-4-ol