(2R,5R)-2,5-dibenzyl-6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-ylamino)-6-oxohexanoic acid

Base Information

Chemical Name:(2R,5R)-2,5-dibenzyl-6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-ylamino)-6-oxohexanoic acid
CAS No.:1400677-67-9
Molecular Formula:C₃₃H₃₈N₂O₅
Molecular Weight:542.675
Hs Code.:

Synonyms:(2R,5R)-2,5-dibenzyl-6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-ylamino)-6-oxohexanoic acid

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Chemical Property of (2R,5R)-2,5-dibenzyl-6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-ylamino)-6-oxohexanoic acid

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Technology Process of (2R,5R)-2,5-dibenzyl-6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-ylamino)-6-oxohexanoic acid

There total 4 articles about (2R,5R)-2,5-dibenzyl-6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-ylamino)-6-oxohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.4%

: 1400675-97-9
(2R,5R)-2,5-dibenzylhexanedioic acid

: (S)-3-amino-1-(2-methoxyphenyl)azepan-2-one hydrochloride

: 1400677-67-9
(2R,5R)-2,5-dibenzyl-6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-ylamino)-6-oxohexanoic acid

Guidance literature:: (2R,5R)-2,5-dibenzylhexanedioic acid; With diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

(S)-3-amino-1-(2-methoxyphenyl)azepan-2-one hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

Reference yield:

: 1400675-98-0
(2S,5S,E)-2,5-dibenzyl-1,6-bis((S)-4-benzyl-2-oxooxazolidin-3-yl)hex-3-ene-1,6-dione

: 1400677-67-9
(2R,5R)-2,5-dibenzyl-6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-ylamino)-6-oxohexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

2.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0.67 h / 0 °C

2.2: pH < 2

3.1: diisopropyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 20 °C

3.2: 2.5 h / 20 °C

With lithium hydroxide monohydrate; hydrogen; dihydrogen peroxide; diisopropyl-carbodiimide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 29311-53-3
(E)-3-hexene-1,6-dioic acid

: 1400677-67-9
(2R,5R)-2,5-dibenzyl-6-((S)-1-(2-methoxyphenyl)-2-oxoazepan-3-ylamino)-6-oxohexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: pivaloyl chloride; 4-methyl-morpholine / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 2.75 h / -78 - 20 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

2.2: 3 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h

4.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0.67 h / 0 °C

4.2: pH < 2

5.1: diisopropyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 20 °C

5.2: 2.5 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; pivaloyl chloride; diisopropyl-carbodiimide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;