(2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one

Base Information

Chemical Name:(2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one
CAS No.:1379762-76-1
Molecular Formula:C₁₈H₁₆O₂
Molecular Weight:264.324
Hs Code.:

Synonyms:(2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one

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Chemical Property of (2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one

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Technology Process of (2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one

There total 3 articles about (2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 54752-32-8
C₁₈H₁₆O

: 1379762-76-1
(2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one

Guidance literature:: With C₂₈H₃₄F₆FeN₆O₆S₂; dihydrogen peroxide; acetic acid; In acetonitrile; at -20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201200992

Reference yield:

: 54752-32-8
C₁₈H₁₆O

: 1379762-76-1
(2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one

: (2S,3'R)-3'-(o-tolyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one

Guidance literature:: C₁₈H₁₆O; With tris(bis(trimethylsilyl)amido)lanthanum(III); (S,S)-N,N'-di(3,5-dimethylsalicylidene)-1,2-cyclohexanediamine; In acetonitrile; for 0.5h; Inert atmosphere;

With tert.-butylhydroperoxide; In acetonitrile; at -20 ℃; for 10h; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c9ra01529a

Reference yield:

: 17215-80-4
2-chloro-1-tetralone

: 529-20-4
2-methylphenyl aldehyde

: 1379762-76-1
(2R,3'S)-3'-(2-methphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one

: (2S,3'R)-3'-(o-tolyl)-3,4-dihydro-1H-spiro[naphthalene-2,2'-oxiran]-1-one

Guidance literature:: 2-chloro-1-tetralone; With C₃₁H₃₈N₂O₈; triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

2-methylphenyl aldehyde; In tetrahydrofuran; at 0 ℃; for 36h; Overall yield = 82 %; enantioselective reaction;
DOI:10.1039/c7cc06194c