5'-O-(4,4'-dimethoxytrityl)-6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine
CAS No.:243657-08-1
Molecular Formula:C₄₁H₄₀N₆O₁₁
Molecular Weight:792.802
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 243657-07-0
6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine

: 243657-08-1
5'-O-(4,4'-dimethoxytrityl)-6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/jo990479h

Reference yield:

: 42855-00-5
nitroveratryloxycarbonyl chloride

: 243657-08-1
5'-O-(4,4'-dimethoxytrityl)-6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: 63 percent / tetrahydrofuran / 20 - 70 °C

3: tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

4: 53 percent / pyridine / 20 °C

With pyridine; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1: Acylation / 2: Acylation / 3: Hydrolysis / 4: Etherification;
DOI:10.1021/jo990479h

Reference yield:

: 6-nitroveratryloxycarbonyltetrazolide

: 243657-08-1
5'-O-(4,4'-dimethoxytrityl)-6-N-(6-nitroveratryloxycarbonyl)-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / tetrahydrofuran / 20 - 70 °C

2: tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

3: 53 percent / pyridine / 20 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1: Acylation / 2: Hydrolysis / 3: Etherification;
DOI:10.1021/jo990479h