3-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Base Information

Chemical Name:3-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid
CAS No.:1354721-80-4
Molecular Formula:C₃₃H₃₂F₃N₅O₄S
Molecular Weight:651.709
Hs Code.:

Synonyms:3-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

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Chemical Property of 3-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

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Technology Process of 3-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

There total 9 articles about 3-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1354722-30-7
C₃₇H₄₀F₃N₅O₄S

: 1354721-80-4
3-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 1354721-80-4
3-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C

2: hydrogen / palladium on activated charcoal / methanol / 4 h / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 28 °C

4: hydrogen / palladium on activated charcoal / dichloromethane; methanol / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 28 °C

6: trifluoroacetic acid / dichloromethane / 20 °C

With dmap; copper(l) iodide; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; L-proline; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1353855-21-6
1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-amine

: 1354721-80-4
3-((3-((4-(piperidin-1-yl)-2-((1-(3-(trifluoromethyl)phenyl)-1H-imidazol-4-yl)carbamoyl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 28 °C

2: hydrogen / palladium on activated charcoal / dichloromethane; methanol / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 28 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;