5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-5-trifluoromethanesulfonate-1,4-dihydro-4-quinolinone

Base Information

Chemical Name:5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-5-trifluoromethanesulfonate-1,4-dihydro-4-quinolinone
CAS No.:645390-06-3
Molecular Formula:C₁₉H₁₆F₃NO₆S
Molecular Weight:443.4
Hs Code.:

Synonyms:5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-5-trifluoromethanesulfonate-1,4-dihydro-4-quinolinone

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Chemical Property of 5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-5-trifluoromethanesulfonate-1,4-dihydro-4-quinolinone

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Technology Process of 5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-5-trifluoromethanesulfonate-1,4-dihydro-4-quinolinone

There total 3 articles about 5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-5-trifluoromethanesulfonate-1,4-dihydro-4-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 645390-03-0
5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-1,4-dihydro-4-quinolinone

: 645390-06-3
5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-5-trifluoromethanesulfonate-1,4-dihydro-4-quinolinone

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2003.09.094

Reference yield:

: 10272-07-8
3.5-dimethoxyaniline

: 645390-06-3
5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-5-trifluoromethanesulfonate-1,4-dihydro-4-quinolinone

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / p-toluenesulfonic acid / ethanol / 24 h / Heating

2: 60 percent / xylene / 8 h / 240 - 250 °C

3: 90 percent / HBr / H₂O; dimethylformamide / 2.5 h / 90 °C

4: 90 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

5: 74 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; xylene;
DOI:10.1016/j.tet.2003.09.094

Reference yield:

: 27834-99-7
ethyl (3-methoxybenzoyl)acetate

: 645390-06-3
5-hydroxy-7-methoxy-2-(3-methoxyphenyl)-1-methyl-5-trifluoromethanesulfonate-1,4-dihydro-4-quinolinone

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / p-toluenesulfonic acid / ethanol / 24 h / Heating

2: 60 percent / xylene / 8 h / 240 - 250 °C

3: 90 percent / HBr / H₂O; dimethylformamide / 2.5 h / 90 °C

4: 90 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

5: 74 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; hydrogen bromide; potassium carbonate; toluene-4-sulfonic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; xylene;
DOI:10.1016/j.tet.2003.09.094