1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Base Information

Chemical Name:1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one
CAS No.:1359759-14-0
Molecular Formula:C₁₉H₂₂N₂O₂
Molecular Weight:310.396
Hs Code.:

Synonyms:1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

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Chemical Property of 1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Chemical Property:

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Technology Process of 1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

There total 5 articles about 1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1359759-14-0
1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol; methanol / 13 h / 23 °C

2: zinc; acetic acid / 0.58 h

3: tetrahydrofuran / 17 h / 23 °C / Reflux

4: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 175 °C / Microwave irradiation

5: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 0.25 h / 125 °C / Inert atmosphere; Microwave irradiation

With sodium hydride; caesium carbonate; acetic acid; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1359761-03-7
5-bromo-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

: 87199-18-6
3-hydroxyphenylboronic acid

: 1359759-14-0
1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 125 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 302800-13-1
5-bromo-N-methyl-2-nitroaniline

: 1359759-14-0
1-(2,2-dimethylpropyl)-5-(3-hydroxyphenyl)-3-methyl-1,3-dihydro-2H-benzimidazol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: zinc; acetic acid / 0.58 h

2: tetrahydrofuran / 17 h / 23 °C / Reflux

3: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 175 °C / Microwave irradiation

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 0.25 h / 125 °C / Inert atmosphere; Microwave irradiation

With sodium hydride; caesium carbonate; acetic acid; zinc; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; N,N-dimethyl-formamide;