(R)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

Base Information

Chemical Name:(R)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide
CAS No.:1312605-61-0
Molecular Formula:C₂₃H₂₀N₈O
Molecular Weight:424.465
Hs Code.:

Synonyms:(R)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

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Chemical Property of (R)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

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Technology Process of (R)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

There total 11 articles about (R)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312606-11-3
2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

: 1312605-60-9
(S)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

: 1312605-61-0
(R)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

Guidance literature:: With AD column; In hexane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 5305-45-3
4,6-dichloro-5-cyanopyrimidine

: 1312605-60-9
(S)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

: 1312605-61-0
(R)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / tetrahydrofuran / 0.83 h

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 105 °C

3: AD column / isopropyl alcohol; hexane / Resolution of racemate

With ammonia; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 7660-48-2
4,6-dichloropyrimidine-5-carbaldehyde oxime

: 1312605-60-9
(S)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

: 1312605-61-0
(R)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-N-methyl-3-phenyl-1,5-naphthyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / chloroform / 2 h / 20 °C

2: ammonia / tetrahydrofuran / 0.83 h

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 105 °C

4: AD column / isopropyl alcohol; hexane / Resolution of racemate

With thionyl chloride; ammonia; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; chloroform; N,N-dimethyl-formamide; isopropyl alcohol;