(S)-benzyl 3-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)pyrazin-2-ylamino)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 3-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)pyrazin-2-ylamino)piperidine-1-carboxylate
CAS No.:1270497-17-0
Molecular Formula:C₂₃H₂₃N₇O₂
Molecular Weight:429.481
Hs Code.:

Synonyms:(S)-benzyl 3-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)pyrazin-2-ylamino)piperidine-1-carboxylate

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Chemical Property of (S)-benzyl 3-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)pyrazin-2-ylamino)piperidine-1-carboxylate

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Technology Process of (S)-benzyl 3-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)pyrazin-2-ylamino)piperidine-1-carboxylate

There total 3 articles about (S)-benzyl 3-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)pyrazin-2-ylamino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1270496-96-2
C₂₉H₃₇N₇O₃Si

: 1270497-17-0
(S)-benzyl 3-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)pyrazin-2-ylamino)piperidine-1-carboxylate

Guidance literature:: C₂₉H₃₇N₇O₃Si; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 40 ℃; for 70h;

With water; In tetrahydrofuran;

Reference yield:

: 1184926-29-1
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine

: 1270497-17-0
(S)-benzyl 3-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)pyrazin-2-ylamino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C

1.2: 1.5 h / -78 - 0 °C

1.3: 72 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 3 h / 230 °C / Inert atmosphere; sealed tube; microwave irradiation

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 70 h / 40 °C

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane;

Reference yield:

: 1270496-95-1
C₁₆H₂₀FN₅OSi

: 1270497-17-0
(S)-benzyl 3-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)pyrazin-2-ylamino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 3 h / 230 °C / Inert atmosphere; sealed tube; microwave irradiation

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 70 h / 40 °C

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;