2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid

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Chemical Name:2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid
CAS No.:951443-78-0
Molecular Formula:C₅₁H₅₀N₂O₁₃S
Molecular Weight:931.03
Hs Code.:

2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid

Synonyms:2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid

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Chemical Property of 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid

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Technology Process of 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid

There total 4 articles about 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (11B)acetic acid [(2R,3S,4R,5R,6S)-3,4-diacetoxy-6-(2,2,2-trichloroethanimidoyl)oxy-5-(2,2,2-trichloroethoxycarbonylamino)tetrahydropyran-2-yl]methyl ester

: 951443-78-0
2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 1 h / 20 °C / Molecular sieve; Inert atmosphere

1.2: 1.5 h / -78 °C

2.1: zinc; acetic acid / 8 h / 20 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / tetrahydrofuran

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; N-methylaniline; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 888788-08-7
(S)-3-((2R,3R,4R,5S,6R)-4,5-Diacetoxy-6-acetoxymethyl-3-amino-tetrahydro-pyran-2-yloxy)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid allyl ester

: 951443-78-0
2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / tetrahydrofuran

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N-methylaniline; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 136497-85-3
N-(9-fluorenylmethoxycarbonyl)-L-serine allyl ester

: 951443-78-0
2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-diacetoxy-6-(acetoxymethyl)-3-(2-mercaptoacetamido)tetrahydro-2H-pyran-2-yloxy)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 1 h / 20 °C / Molecular sieve; Inert atmosphere

1.2: 1.5 h / -78 °C

2.1: zinc; acetic acid / 8 h / 20 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline / tetrahydrofuran

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; N-methylaniline; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;