1-(2-Hydroxyethyl)-4-piperidone

Base Information

Chemical Name:1-(2-Hydroxyethyl)-4-piperidone
CAS No.:84394-97-8
Molecular Formula:C7H13 N O2
Molecular Weight:143.186
Hs Code.:
European Community (EC) Number:282-755-8
UNII:KT2EEE69EE
DSSTox Substance ID:DTXSID10233367
Nikkaji Number:J297.666H
Wikidata:Q83114862
Mol file:84394-97-8.mol

Synonyms:84394-97-8;1-(2-Hydroxyethyl)piperidin-4-one;1-(2-Hydroxyethyl)-4-piperidone;EINECS 282-755-8;1-(2-HYDROXYETHYL)-4-PIPERIDINONE;KT2EEE69EE;SCHEMBL2958326;DTXSID10233367;UIFFSBYMUXSQNX-UHFFFAOYSA-N;AKOS000166765;4-Piperidinone, 1-(2-hydroxyethyl)-;NS00038501;EN300-258097

Suppliers and Price of 1-(2-Hydroxyethyl)-4-piperidone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
1-(2-HYDROXYETHYL)-4-PIPERIDINONE 95
2g
$ 1467.00

American Custom Chemicals Corporation
1-(2-HYDROXYETHYL)-4-PIPERIDINONE 95.00%
5MG
$ 495.87

AccelPharmtech
1-(2-hydroxyethyl)-4-Piperidinone 97.00%
5G
$ 3300.00

AccelPharmtech
1-(2-hydroxyethyl)-4-Piperidinone 97.00%
1G
$ 1950.00

Total 3 raw suppliers

Chemical Property of 1-(2-Hydroxyethyl)-4-piperidone

Chemical Property:

Vapor Pressure:0.000252mmHg at 25°C
Boiling Point:288.9°C at 760 mmHg
PKA:14.90±0.10(Predicted)
Flash Point:128.5°C
PSA：40.54000
Density:1.109g/cm³
LogP:-0.41850
XLogP3:-1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:143.094628657
Heavy Atom Count:10
Complexity:115

Purity/Quality:

99% ^*data from raw suppliers

1-(2-HYDROXYETHYL)-4-PIPERIDINONE 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1=O)CCO

Technology Process of 1-(2-Hydroxyethyl)-4-piperidone

There total 2 articles about 1-(2-Hydroxyethyl)-4-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 85997-58-6
N-(2-hydroxyethyl)-N-(3-methoxy-3-oxopropyl)-β-alanine

: 84394-97-8
1-(2-hydroxyethyl)piperidin-4-one

Guidance literature:: With sodium methylate; In toluene; at 110 ℃; for 5h;
DOI:10.1016/j.ejmech.2017.07.051

Reference yield:

: C₁₀H₁₇NO₄

: 84394-97-8
1-(2-hydroxyethyl)piperidin-4-one

Guidance literature:: With hydrogenchloride; water; at 100 ℃; for 4h;
DOI:10.1016/j.bmcl.2011.06.012

Reference yield:

: 84394-97-8
1-(2-hydroxyethyl)piperidin-4-one

: (S)-3-(4-(azetidine-1-carbonyl)phenoxy)-N-(5-(2-hydroxyethyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-5-((1-methoxypropan-2-yl)oxy)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyrrolidine / isopropyl alcohol / 2 h / 55 °C

1.2: 6 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With pyrrolidine; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.ejmech.2017.07.051