1,2-Bis-(2-hydroxyethoxy)-cyclohexan

Base Information

• Chemical Name: 1,2-Bis-(2-hydroxyethoxy)-cyclohexan
• CAS No.: 75503-88-7
• Molecular Formula: C₁₀H₂₀O₄
• Molecular Weight: 204.266
• Mol file: 75503-88-7.mol

Synonyms:1,2-Bis-(2-hydroxyethoxy)-cyclohexan

Chemical Property of 1,2-Bis-(2-hydroxyethoxy)-cyclohexan

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1,2-Bis-(2-hydroxyethoxy)-cyclohexan

There total 3 articles about 1,2-Bis-(2-hydroxyethoxy)-cyclohexan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2'-(1,2-phenylenedioxy)diethanol (10234-40-9) → 1,2-Bis-(2-hydroxyethoxy)-cyclohexan (75503-88-7)

Guidance literature:

With hydrogen; aluminum oxide; ruthenium; at 100 ℃; under 60800 Torr; (hydrogenation);

DOI:10.1055/s-1978-24716

Reference yield:

trans-1,2-cyclohexandiol (1460-57-7) → 2-[(1R,2R)-2-(2-Hydroxy-ethoxy)-cyclohexyloxy]-ethanol (62583-84-0,62623-97-6,66513-48-2,66513-49-3,75503-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 50percent aq. sodium hydroxide / tetrabutylammonium hydrogen sulfate / 72 h / 65 °C

2: aq. HCl / methanol; CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In methanol; dichloromethane;

DOI:10.1021/jo00265a026

Reference yield:

C20H36O6 → 2-[(1R,2R)-2-(2-Hydroxy-ethoxy)-cyclohexyloxy]-ethanol (62583-84-0,62623-97-6,66513-48-2,66513-49-3,75503-88-7)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane; for 2h; Yield given; Ambient temperature;

DOI:10.1021/jo00265a026

upstream raw materials:

2,2'-(1,2-phenylenedioxy)diethanol

trans-1,2-cyclohexandiol

Downstream raw materials:

perhydrodibenzo-18-crown-6

1,2-Bis-(2-chlorethoxy)-cyclohexan

Refernces