cyclo-N^ε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine

Base Information

• Chemical Name: cyclo-N^ε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine
• CAS No.: 440353-79-7
• Molecular Formula: C₃₅H₅₆N₈O₆
• Molecular Weight: 684.88

Synonyms:cyclo-N^ε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine

Chemical Property of cyclo-N^ε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclo-N^ε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine

There total 8 articles about cyclo-N^ε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Nε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine trifluoroacetate → cyclo-Nε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine (440353-79-7)

Guidance literature:

With diphenylphosphoranyl azide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 53h;

DOI:10.1021/jo016276m

Reference yield:

(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-methyl-butyric acid (68802-93-7) → cyclo-Nε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine (440353-79-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 180 mg / EDAC*HCl; 1-hydroxy-7-azabenzotriazole / tetrahydrofuran / 54 h / 20 °C

2: 82 percent / LiOH / tetrahydrofuran; methanol; H₂O / 3.5 h / 0 - 20 °C

3: 94 percent / 0.5 h / 0 °C

4: 85 percent / NaHCO₃; diphenylphosphoryl azide / dimethylformamide / 53 h / 0 - 20 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; diphenylphosphoranyl azide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jo016276m

Reference yield:

(+/-)-trans-3-azido-4-undecyl-2-azetidinone → cyclo-Nε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine (440353-79-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 82 percent / 4-dimethylaminopyridine / acetonitrile / 0.33 h

2: 84 percent / diisopropylethylamine; sodium azide / dimethylformamide / 20 °C

3: hydrogen chloride / diethyl ether / 0.5 h

4: 180 mg / EDAC*HCl; 1-hydroxy-7-azabenzotriazole / tetrahydrofuran / 54 h / 20 °C

5: 82 percent / LiOH / tetrahydrofuran; methanol; H₂O / 3.5 h / 0 - 20 °C

6: 94 percent / 0.5 h / 0 °C

7: 85 percent / NaHCO₃; diphenylphosphoryl azide / dimethylformamide / 53 h / 0 - 20 °C

With hydrogenchloride; dmap; lithium hydroxide; sodium azide; 1-hydroxy-7-aza-benzotriazole; diphenylphosphoranyl azide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo016276m

upstream raw materials:

(S)-2-((S)-6-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-hexanoylamino)-3-methyl-butyric acid

N^ε-(benzyloxycarbonyl)-N^α-(tert-butoxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 440353-79-7 cyclo-N^ε-(benzyloxycarbonyl)-L-lysyl-L-valyl-(2-azido-3-undecyl-β-alanyl)glycine

Send

Send

Metric Ton KG G Pound L ML

Send

Send