ethyl (E,4S)-4-[{(2S)-2-[(2-methoxy-3-methyl-3-phenylbutanoyl)amino]-3,3-dimethylbutanoyl}(methyl)amino]-2,5-dimethyl-2-hexenoate

Base Information

Chemical Name:ethyl (E,4S)-4-[{(2S)-2-[(2-methoxy-3-methyl-3-phenylbutanoyl)amino]-3,3-dimethylbutanoyl}(methyl)amino]-2,5-dimethyl-2-hexenoate
CAS No.:845292-39-9
Molecular Formula:C₂₉H₄₆N₂O₅
Molecular Weight:502.695
Hs Code.:

Synonyms:ethyl (E,4S)-4-[{(2S)-2-[(2-methoxy-3-methyl-3-phenylbutanoyl)amino]-3,3-dimethylbutanoyl}(methyl)amino]-2,5-dimethyl-2-hexenoate

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Chemical Property of ethyl (E,4S)-4-[{(2S)-2-[(2-methoxy-3-methyl-3-phenylbutanoyl)amino]-3,3-dimethylbutanoyl}(methyl)amino]-2,5-dimethyl-2-hexenoate

Chemical Property:

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Technology Process of ethyl (E,4S)-4-[{(2S)-2-[(2-methoxy-3-methyl-3-phenylbutanoyl)amino]-3,3-dimethylbutanoyl}(methyl)amino]-2,5-dimethyl-2-hexenoate

There total 5 articles about ethyl (E,4S)-4-[{(2S)-2-[(2-methoxy-3-methyl-3-phenylbutanoyl)amino]-3,3-dimethylbutanoyl}(methyl)amino]-2,5-dimethyl-2-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 765931-01-9
2-methoxy-3-methyl-3-phenylbutanoic acid

: 610786-70-4
ethyl (S,E)-4-((S)-2-amino-N,3,3-trimethylbutanamide)-2,5-dimethylhexa-2-enoate hydrochloride

: 845292-39-9
ethyl (E,4S)-4-[{(2S)-2-[(2-methoxy-3-methyl-3-phenylbutanoyl)amino]-3,3-dimethylbutanoyl}(methyl)amino]-2,5-dimethyl-2-hexenoate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm040056u

Reference yield:

: 91133-59-4
3-methyl-3-phenyl-2-oxobutanoic acid

: 845292-39-9
ethyl (E,4S)-4-[{(2S)-2-[(2-methoxy-3-methyl-3-phenylbutanoyl)amino]-3,3-dimethylbutanoyl}(methyl)amino]-2,5-dimethyl-2-hexenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / methanol; diethyl ether; hexane / 0 °C

2: 80 percent / NaBH₄ / methanol / 0.67 h / 0 - 20 °C

3: 68 percent / silver(I) oxide / diethyl ether / 26 h / 40 °C

4: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 16 h / 60 °C

5: PyBOP; diisopropylethylamine / dimethylformamide / 0 - 20 °C

With lithium hydroxide; sodium tetrahydroborate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In tetrahydrofuran; methanol; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm040056u

Reference yield:

: 77586-78-8
(+/-)-methyl 2-hydroxy-3-methyl-3-phenylbutanoate

: 845292-39-9
ethyl (E,4S)-4-[{(2S)-2-[(2-methoxy-3-methyl-3-phenylbutanoyl)amino]-3,3-dimethylbutanoyl}(methyl)amino]-2,5-dimethyl-2-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / silver(I) oxide / diethyl ether / 26 h / 40 °C

2: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 16 h / 60 °C

3: PyBOP; diisopropylethylamine / dimethylformamide / 0 - 20 °C

With lithium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm040056u