N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide

Base Information

Chemical Name:N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide
CAS No.:947371-20-2
Molecular Formula:C₂₇H₂₅F₄N₃O₃
Molecular Weight:515.507
Hs Code.:

Synonyms:N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide

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Chemical Property of N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide

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Technology Process of N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide

There total 10 articles about N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₆BF₄N₃O₄

: 947371-20-2
N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide

Guidance literature:: With Oxone; sodium hydroxide; sodium hydrogencarbonate; In tetrahydrofuran; acetone; at 0 ℃; for 0.166667h;
DOI:10.1021/jm070131b

Reference yield:

: C₁₀H₈FNO

: 947371-20-2
N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide

Guidance literature:: Multi-step reaction with 9 steps

1: cesium carbonate / acetonitrile / 0 - 20 °C

2: sodium borohydride / methanol / -78 - 0 °C

3: triethylamine / ethyl acetate / 1 h / 0 °C

4: sodium azide / dimethylformamide / 110 °C

5: hydrogen / platinium dioxide / ethyl acetate

6: hydrogen chloride / dioxane / 20 °C

7: PyBop; N-methylmorpholine / CH₂Cl₂ / 20 °C

8: potassium acetate; tricyclohexylphosphine; tris(dibenzylideneacetone)dipalladium / dioxane / 20 - 95 °C

9: aq. oxone; sodium hydroxide; sodium bicarbonate / acetone; tetrahydrofuran / 0.17 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; Oxone; sodium hydroxide; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium acetate; sodium hydrogencarbonate; caesium carbonate; triethylamine; tricyclohexylphosphine; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm070131b

Reference yield:

: C₁₇H₁₃FClNO

: 947371-20-2
N-[(1S,2S)-2-(3-cyano-5-fluorophenyl)-3-(4-hydroxyphenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium borohydride / methanol / -78 - 0 °C

2: triethylamine / ethyl acetate / 1 h / 0 °C

3: sodium azide / dimethylformamide / 110 °C

4: hydrogen / platinium dioxide / ethyl acetate

5: hydrogen chloride / dioxane / 20 °C

6: PyBop; N-methylmorpholine / CH₂Cl₂ / 20 °C

7: potassium acetate; tricyclohexylphosphine; tris(dibenzylideneacetone)dipalladium / dioxane / 20 - 95 °C

8: aq. oxone; sodium hydroxide; sodium bicarbonate / acetone; tetrahydrofuran / 0.17 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; Oxone; sodium hydroxide; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; potassium acetate; sodium hydrogencarbonate; triethylamine; tricyclohexylphosphine; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm070131b