(3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Base Information

Chemical Name:(3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine
CAS No.:1351338-51-6
Molecular Formula:C₂₅H₃₀F₃N₇O₂
Molecular Weight:517.554
Hs Code.:

Synonyms:(3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Suppliers and Price of (3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

There total 10 articles about (3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351345-52-2
[(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351338-51-6
(3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Guidance literature:: [(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydroxide; In ethyl acetate;

Reference yield:

: 936251-01-3
[(trans)-1-benzyl-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351338-51-6
(3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 5%-palladium/activated carbon / toluene; industrial methylated spirit / 72 h / Inert atmosphere; autoclave

2: (2S)-2-(6-methoxy(2-naphthyl))propanoic acid / ethanol / 20 °C / Reflux

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 144 h / 85 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogen; (2S)-2-(6-methoxy(2-naphthyl))propanoic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; 5%-palladium/activated carbon; In industrial methylated spirit; ethanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: (trans)-1-benzyl-3-(2,4,5-trifluorophenyl)-4-nitropyrrolidine

: 1351338-51-6
(3R,4S)-1-{5-[l-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: zinc; acetic acid / industrial methylated spirit / 65 °C

2: triethylamine / tetrahydrofuran / 16.08 h / 0 - 20 °C

3: hydrogen / 5%-palladium/activated carbon / toluene; industrial methylated spirit / 72 h / Inert atmosphere; autoclave

4: (2S)-2-(6-methoxy(2-naphthyl))propanoic acid / ethanol / 20 °C / Reflux

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 144 h / 85 °C / Inert atmosphere

6: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogen; (2S)-2-(6-methoxy(2-naphthyl))propanoic acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; zinc; 5%-palladium/activated carbon; In tetrahydrofuran; industrial methylated spirit; ethanol; dichloromethane; dimethyl sulfoxide; toluene;