2-iodo-1-(4-methylbenzoyl)-3-phenylindolizine-8-carbaldehyde

Base Information

• Chemical Name: 2-iodo-1-(4-methylbenzoyl)-3-phenylindolizine-8-carbaldehyde
• CAS No.: 1398567-29-7
• Molecular Formula: C₂₃H₁₆INO₂
• Molecular Weight: 465.29
• Mol file: 1398567-29-7.mol

Synonyms:2-iodo-1-(4-methylbenzoyl)-3-phenylindolizine-8-carbaldehyde

Chemical Property of 2-iodo-1-(4-methylbenzoyl)-3-phenylindolizine-8-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-iodo-1-(4-methylbenzoyl)-3-phenylindolizine-8-carbaldehyde

There total 3 articles about 2-iodo-1-(4-methylbenzoyl)-3-phenylindolizine-8-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-methoxy-8-(phenylethynyl)-7-p-tolyl-5H-pyrano[4,3-b]pyridine (1398566-94-3) → 2-iodo-1-(4-methylbenzoyl)-3-phenylindolizine-8-carbaldehyde (1398567-29-7)

Guidance literature:

With iodine; In dichloromethane; at 25 ℃;

DOI:10.1021/jo3015374

Reference yield:

8-iodo-5-methoxy-7-(p-tolyl)-5H-pyrano[4,3-b]pyridine (1398567-34-4) → 2-iodo-1-(4-methylbenzoyl)-3-phenylindolizine-8-carbaldehyde (1398567-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

2: iodine / dichloromethane / 25 °C

With bis-triphenylphosphine-palladium(II) chloride; iodine; diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;

DOI:10.1021/jo3015374

Reference yield:

2-p-tolylethynylpyridine-3-carbaldehyde (1398567-32-2) → 2-iodo-1-(4-methylbenzoyl)-3-phenylindolizine-8-carbaldehyde (1398567-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1: iodine; potassium carbonate / dichloromethane / 25 °C

2: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

3: iodine / dichloromethane / 25 °C

With bis-triphenylphosphine-palladium(II) chloride; iodine; potassium carbonate; diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;

DOI:10.1021/jo3015374

upstream raw materials:

8-iodo-5-methoxy-7-(p-tolyl)-5H-pyrano[4,3-b]pyridine

5-methoxy-8-(phenylethynyl)-7-p-tolyl-5H-pyrano[4,3-b]pyridine

2-p-tolylethynylpyridine-3-carbaldehyde