4-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol

Base Information

Chemical Name:4-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol
CAS No.:1201447-01-9
Molecular Formula:C₂₁H₁₉F₃N₂O₃
Molecular Weight:404.389
Hs Code.:

Synonyms:4-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol

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Chemical Property of 4-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol

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Technology Process of 4-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol

There total 3 articles about 4-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 213598-16-4
4-isopropoxy-3-(trifluoromethyl)benzoic acid

: 1093827-51-0
N',1-dihydroxy-2,3-dihydro-1H-indene-4-carboximidamide

: 1201447-01-9
4-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol

Guidance literature:: 4-isopropoxy-3-(trifluoromethyl)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

N',1-dihydroxy-2,3-dihydro-1H-indene-4-carboximidamide; In N,N-dimethyl-formamide; at 20 - 130 ℃; for 1.08333h; Microwave irradiation;

Reference yield:

: 125114-76-3,1306763-24-5
(±)-1-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile

: 1201447-01-9
4-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 16 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C

2.2: 1.08 h / 20 - 130 °C / Microwave irradiation

With hydroxylamine hydrochloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 60899-34-5
4-cyano-2,3-dihydro-1H-inden-1-one

: 1201447-01-9
4-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; ethanol; silica gel / 0 - 20 °C

2.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 16 h / Reflux

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C

3.2: 1.08 h / 20 - 130 °C / Microwave irradiation

With sodium tetrahydroborate; ethanol; hydroxylamine hydrochloride; silica gel; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;