2(1H)-Phenanthrenone, 3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-, (4aS,10aR)-

Base Information

Chemical Name:2(1H)-Phenanthrenone, 3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-, (4aS,10aR)-
CAS No.:305822-61-1
Molecular Formula:C₂₁H₂₂O₂
Molecular Weight:306.404
Hs Code.:
Mol file:305822-61-1.mol

Synonyms:2(1H)-phenanthrenone, 3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-, (4aS-trans)-

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Chemical Property of 2(1H)-Phenanthrenone, 3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-, (4aS,10aR)-

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Technology Process of 2(1H)-Phenanthrenone, 3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-, (4aS,10aR)-

There total 11 articles about 2(1H)-Phenanthrenone, 3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-, (4aS,10aR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 305822-57-5
2(3H)-phenanthrenone, 4,4a,9,10-tetrahydro-7-hydroxy-4a-(phenylmethyl)-, (S)

: 305822-61-1
2(1H)-phenanthrenone, 3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-, (4aS-trans)-

Guidance literature:: With lithium amide; In 1,4-dioxane; diethyl ether; at -78 ℃; for 0.5h;
DOI:10.1021/jm0105530

Reference yield: 81.0%

: 305822-57-5
2(3H)-phenanthrenone, 4,4a,9,10-tetrahydro-7-hydroxy-4a-(phenylmethyl)-, (S)

: (4aS)-cis-3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-2(1H)-phenanthrenone

: 305822-61-1
2(1H)-phenanthrenone, 3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-, (4aS-trans)-

Guidance literature:: With ammonia; lithium; In 1,4-dioxane; diethyl ether; at -78 ℃; for 0.5h;

Reference yield:

: 2472-22-2
6-methoxy-2-tetralone

: 305822-61-1
2(1H)-phenanthrenone, 3,4,4a,9,10,10a-hexahydro-7-hydroxy-4a-(phenylmethyl)-, (4aS-trans)-

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene / Heating

2.1: dioxane / Heating

3.1: H₂O / dioxane / 2 h / Heating

4.1: toluene / Heating

5.1: toluene / 0 - 40 °C

5.2: 48 g / aq. AcOH / toluene / 2 h / 0 - 20 °C

6.1: 35 g / NaOMe / methanol / 3.25 h / 20 - 75 °C

7.1: 87 percent / BCl₃; Bu₄NI / CH₂Cl₂ / 1.5 h / -78 - 20 °C

8.1: 81 percent / LiNH₂ / dioxane; diethyl ether / 0.5 h / -78 °C

With lithium amide; water; sodium methylate; boron trichloride; tetra-(n-butyl)ammonium iodide; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm0105530