(+)-cis-7-Methoxy-3-phenyl-4-{4-{2-(pyrrolidin-1-yl)ethoxy}phenyl}chromane

Base Information

Chemical Name:(+)-cis-7-Methoxy-3-phenyl-4-{4-{2-(pyrrolidin-1-yl)ethoxy}phenyl}chromane
CAS No.:207278-54-4
Molecular Formula:C₂₈H₃₁NO₃
Molecular Weight:429.559
Hs Code.:

Synonyms:(+)-cis-7-Methoxy-3-phenyl-4-{4-{2-(pyrrolidin-1-yl)ethoxy}phenyl}chromane

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Chemical Property of (+)-cis-7-Methoxy-3-phenyl-4-{4-{2-(pyrrolidin-1-yl)ethoxy}phenyl}chromane

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Technology Process of (+)-cis-7-Methoxy-3-phenyl-4-{4-{2-(pyrrolidin-1-yl)ethoxy}phenyl}chromane

There total 5 articles about (+)-cis-7-Methoxy-3-phenyl-4-{4-{2-(pyrrolidin-1-yl)ethoxy}phenyl}chromane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18196-35-5,33382-09-1,33382-12-6
cis-4-(4-hydroxyphenyl)-7-methoxy-3-phenylchromane

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 207278-54-4,18196-29-7,33382-06-8,33382-08-0
(+)-cis-7-Methoxy-3-phenyl-4-{4-{2-(pyrrolidin-1-yl)ethoxy}phenyl}chromane

Guidance literature:: With sodium hydroxide; In methanol; water; toluene;

Reference yield:

: 33257-83-9
4-(4-hydroxyphenyl)-7-methoxy-3-phenyl-2H-chromen-2-one

: 207278-54-4,18196-29-7,33382-06-8,33382-08-0
(+)-cis-7-Methoxy-3-phenyl-4-{4-{2-(pyrrolidin-1-yl)ethoxy}phenyl}chromane

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiAlH₄ / tetrahydrofuran / 0.5 h

1.2: 81 percent / 6M HCl / 1 h / 60 °C

2.1: 81 percent / H₂ / Pd/C / ethanol / 18 h

3.1: NaOH / toluene; H₂O / 4 h / 75 °C

3.2: (-)-di-p-toluoyl-L-tartaric acid / butan-1-ol / 60 - 75 °C

3.3: 10M NaOH / toluene; H₂O; ethyl acetate / pH 11

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1016/S0968-0896(01)00257-7

Reference yield:

: 13417-73-7
4-(p-hydroxyphenyl)-3-phenyl-7-methoxy-2H-chromene

: 207278-54-4,18196-29-7,33382-06-8,33382-08-0
(+)-cis-7-Methoxy-3-phenyl-4-{4-{2-(pyrrolidin-1-yl)ethoxy}phenyl}chromane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / H₂ / Pd/C / ethanol / 18 h

2.1: NaOH / toluene; H₂O / 4 h / 75 °C

2.2: (-)-di-p-toluoyl-L-tartaric acid / butan-1-ol / 60 - 75 °C

2.3: 10M NaOH / toluene; H₂O; ethyl acetate / pH 11

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; water; toluene;
DOI:10.1016/S0968-0896(01)00257-7