(3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol

Base Information

Chemical Name:(3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol
CAS No.:423772-45-6
Molecular Formula:C₅₆H₉₆O₉Si₃
Molecular Weight:997.629
Hs Code.:

(3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol

Synonyms:(3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol

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Chemical Property of (3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol

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Technology Process of (3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol

There total 9 articles about (3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-1-methoxy-3,5,9,11-tetramethyl-tetradecane-1,4-diol

: 423772-45-6
(3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃;
DOI:10.1016/S0040-4020(01)01206-6

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 423772-45-6
(3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / 2,6-lutidine / CH₂Cl₂ / 2.5 h / 0 °C

2: HCl / H₂O; 1,2-dimethoxy-ethane / 20 °C

3: NaBH₄ / ethanol / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; In 1,2-dimethoxyethane; ethanol; dichloromethane; water;
DOI:10.1016/S0040-4020(01)01206-6

Reference yield:

: 67680-46-0
<(3,4-dimethoxybenzyl)oxy>methyl chloride

: 423772-45-6
(3R,4R,5R,6R,9S,10S,11R,12S)-10,12-Bis-(tert-butyl-dimethyl-silanyloxy)-14-(tert-butyl-diphenyl-silanyloxy)-6-(3,4-dimethoxy-benzyloxymethoxy)-3,5,9,11-tetramethyl-tetradecane-1,4-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / i-Pr₂NEt / CH₂Cl₂ / 13 h / 20 °C

2: 90 percent / AcOH / tetrahydrofuran; H₂O / 20 °C

3: 100 percent / 2,6-lutidine / CH₂Cl₂ / 2.5 h / 0 °C

4: HCl / H₂O; 1,2-dimethoxy-ethane / 20 °C

5: NaBH₄ / ethanol / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water;
DOI:10.1016/S0040-4020(01)01206-6