diethyl N-<4--N-(5-uracilylmethyl)amino>benzoyl>-L-glutamate hydrobromide

Base Information

• Chemical Name: diethyl N-<4--N-(5-uracilylmethyl)amino>benzoyl>-L-glutamate hydrobromide
• CAS No.: 97280-30-3
• Molecular Formula: BrH*2C₃₀H₃₃N₇O₈
• Molecular Weight: 1320.18

Synonyms:diethyl N-<4--N-(5-uracilylmethyl)amino>benzoyl>-L-glutamate hydrobromide

Chemical Property of diethyl N-<4--N-(5-uracilylmethyl)amino>benzoyl>-L-glutamate hydrobromide

Chemical Property:

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Technology Process of diethyl N-<4--N-(5-uracilylmethyl)amino>benzoyl>-L-glutamate hydrobromide

There total 3 articles about diethyl N-<4--N-(5-uracilylmethyl)amino>benzoyl>-L-glutamate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide (77766-62-2) + diethyl N-<4-<(5-uracilylmethyl)amino>benzoyl>-L-glutamate (80015-04-9) → diethyl N-<4--N-(5-uracilylmethyl)amino>benzoyl>-L-glutamate hydrobromide (97280-30-3)

Guidance literature:

With calcium carbonate; In N,N-dimethyl acetamide; at 25 ℃; for 97h;

DOI:10.1021/jm00148a016

Reference yield:

5-chloromethyluracil (3590-48-5) → diethyl N-<4--N-(5-uracilylmethyl)amino>benzoyl>-L-glutamate hydrobromide (97280-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 23 percent / CaCO₃ / N,N-dimethyl-acetamide / 90 h / 25 °C

2: 21 percent / CaCO₃ / N,N-dimethyl-acetamide / 97 h / 25 °C

With calcium carbonate; In N,N-dimethyl acetamide;

DOI:10.1021/jm00148a016

Reference yield:

diethyl N-(p-aminobenzoyl)-L-glutamate (13726-52-8) → diethyl N-<4--N-(5-uracilylmethyl)amino>benzoyl>-L-glutamate hydrobromide (97280-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 23 percent / CaCO₃ / N,N-dimethyl-acetamide / 90 h / 25 °C

2: 21 percent / CaCO₃ / N,N-dimethyl-acetamide / 97 h / 25 °C

With calcium carbonate; In N,N-dimethyl acetamide;

DOI:10.1021/jm00148a016

upstream raw materials:

2-amino-6-(bromomethyl)-4-hydroxyquinazoline hydrobromide

diethyl N-<4-<(5-uracilylmethyl)amino>benzoyl>-L-glutamate

5-chloromethyluracil

diethyl N-(p-aminobenzoyl)-L-glutamate

Downstream raw materials:

(S)-2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-amino]-benzoylamino}-pentanedioic acid

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